Proteome analysis of rat liver mitochondria reveals a possible compensatory response to endotoxic shock
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چکیده
منابع مشابه
Different effects of endotoxic shock on the respiratory function of liver and heart mitochondria in rats.
This study was designed to clarify whether mitochondrial function/dysfunction and reactive oxygen species (ROS) production have a temporal relationship with organ failure during endotoxic shock. Adult male Sprague-Dawley rats were divided into three groups receiving 1) isotonic saline (control group, n = 16); 2) 8 mg/kg lipopolysaccharide (LPS; n = 8); or 3) 20 mg/kg LPS (n = 8) intraperitoneal...
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15 صفحه اولBacteraemic and endotoxic shock.
In 1924 Sanarelli recorded that endotoxins of Gram-negative organisms would damage capillary and postcapillary venular endothelium. By 1935 it was known that two spaced doses of endotoxin given to rabbits would cause renal cortical necrosis and foci of damage in many organs, the Shwartzman reaction. This is due to a combination of vasospasm and intravascular coagulation. Human equivalents of th...
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Mitochondrial dysfunction is associated with many human diseases. Mitochondrial damage is exacerbated by inadequate protein quality control and often further contributes to pathogenesis. The maintenance of mitochondrial functions requires a delicate balance of continuous protein synthesis and degradation, i.e. protein turnover. To understand mitochondrial protein dynamics in vivo, we designed a...
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Previous studies demonstrated that CSE induces oxidative stress and its consequences on isolated mitochondria obtained from lung, heart and brain which may provide insight into the role of CSE in human health and disease. The present study was carried out to further characterize and compare toxic effect of CSE extract on isolated mitochondria obtained from either a directly contacting tissue (i...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2006
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2006.01.040